{"id":48385,"date":"2023-04-22T12:29:41","date_gmt":"2023-04-22T10:29:41","guid":{"rendered":"https:\/\/newserver.fyb.de\/m4-award-winner-tubulis-enters-into-billion-dollar-agreement-with-bms\/"},"modified":"2023-04-22T12:29:41","modified_gmt":"2023-04-22T10:29:41","slug":"m4-award-winner-tubulis-enters-into-billion-dollar-agreement-with-bms","status":"publish","type":"post","link":"https:\/\/www.fyb.de\/en\/m4-award-winner-tubulis-enters-into-billion-dollar-agreement-with-bms\/","title":{"rendered":"m4 Award winner Tubulis enters into billion-dollar agreement with BMS"},"content":{"rendered":"

Munich\/ Martins\u00adried, Germany \u2014 Tubu\u00adlis and Bris\u00adtol Myers Squibb have ente\u00adred into a stra\u00adte\u00adgic license agree\u00adment for the deve\u00adlo\u00adp\u00adment of diffe\u00adren\u00adtia\u00adted anti\u00adbody-drug conju\u00adga\u00adtes (ADCs). Under the terms of the license agree\u00adment, Bris\u00adtol Myers Squibb will receive exclu\u00adsive rights to Tubu\u00adlis\u2019 proprie\u00adtary conju\u00adga\u00adtion plat\u00adforms for the deve\u00adlo\u00adp\u00adment of a select number of highly diffe\u00adren\u00adtia\u00adted ADCs for the treat\u00adment of solid tumors. The agree\u00adment includes an upfront payment of $22.75 million to Tubu\u00adlis and poten\u00adtial mile\u00adstone payments in excess of $1 billion for deve\u00adlo\u00adp\u00adment, regu\u00adla\u00adtory appr\u00adoval and commer\u00adcia\u00adliza\u00adtion, as well as royal\u00adties on the resul\u00adting marke\u00adted products.<\/b><\/p>\n

Tubu\u00adlis, based in Martins\u00adried, Germany, and Bris\u00adtol Myers Squibb<\/b> (BMS) intend to use the stra\u00adte\u00adgic part\u00adner\u00adship to further advance the deve\u00adlo\u00adp\u00adment of anti\u00adbody-drug conju\u00adga\u00adtes (ADC). BMS will gain access to Tubu\u00adlis\u2019 proprie\u00adtary P5 conju\u00adga\u00adtion and Tubu\u00adte\u00adcan plat\u00adforms to deve\u00adlop versa\u00adtile and custo\u00admizable ADCs for cancer treatment.<\/p>\n

The Tubu\u00adlis P5 and Tubu\u00adte\u00adcan plat\u00adforms enable the produc\u00adtion of ultra-stable ADCs with the poten\u00adtial to actively reduce unwan\u00adted target-inde\u00adpen\u00addent toxi\u00adci\u00adties. At the same time, they are opti\u00admi\u00adzed for targe\u00adted deli\u00advery of potent topoisomerase\u20111 inhi\u00adbi\u00adtors. Follo\u00adwing Bris\u00adtol Myers Squib\u00adb\u2019s selec\u00adtion of the target, Tubu\u00adlis will provide the company with its linker payloads to gene\u00adrate a uniquely matched ADC for each antibody.<\/p>\n

Bris\u00adtol Myers Squibb will assume sole respon\u00adsi\u00adbi\u00adlity for the deve\u00adlo\u00adp\u00adment, manu\u00adfac\u00adtu\u00adring and commer\u00adcia\u00adliza\u00adtion of the resul\u00adting ADC candidates.<\/p>\n

Almost exactly a year ago, m4<\/sup> Award<\/a> winner Tubu\u00adlis<\/b> had announ\u00adced a major success, successfully closing<\/a> a Series B finan\u00adcing of \u20ac60 million<\/a>.<\/p>\n

\u201cThis stra\u00adte\u00adgic agree\u00adment with Bris\u00adtol Myers Squibb is an important vali\u00adda\u00adtion of the poten\u00adtial of our approach to deve\u00adlo\u00adping next-gene\u00adra\u00adtion ADC-based thera\u00adpeu\u00adtics and our state-of-the-art ADC conju\u00adga\u00adtion tech\u00adno\u00adlo\u00adgies that enable advan\u00adced ADC design to treat tumors with high unmet medi\u00adcal need,\u201d said Domi\u00adnik Schu\u00adma\u00adcher, M.D.<\/b>, CEO and co-foun\u00adder of Tubu\u00adlis. He sees the colla\u00adbo\u00adra\u00adtion with BMS as a signi\u00adfi\u00adcant step \u201cin chan\u00adging onco\u00adlogy treat\u00adment para\u00addigms and achie\u00adving better outco\u00admes for cancer patients.\u201d<\/p>\n

\u201cADCs play a promi\u00adsing role in cancer therapy, and Tubu\u00adlis\u2019 diffe\u00adren\u00adtia\u00adted tech\u00adno\u00adlo\u00adgies offer oppor\u00adtu\u00adni\u00adties to over\u00adcome current chal\u00adlenges in deve\u00adlo\u00adping safe and effec\u00adtive ADC thera\u00adpeu\u00adtics,\u201d said Dr. Emma Lees<\/b>, senior vice presi\u00addent, rese\u00adarch and early deve\u00adlo\u00adp\u00adment and head of the Thema\u00adtic Rese\u00adarch Center for Mecha\u00adnisms of Cancer Resis\u00adtance at Bris\u00adtol Myers Squibb.<\/p>\n","protected":false},"excerpt":{"rendered":"

Munich\/ Martins\u00adried, Germany \u2014 Tubu\u00adlis and Bris\u00adtol Myers Squibb have ente\u00adred into a stra\u00adte\u00adgic license agree\u00adment for the deve\u00adlo\u00adp\u00adment of diffe\u00adren\u00adtia\u00adted anti\u00ad\u00adbody-drug conju\u00adga\u00adtes (ADCs). Under the terms of the license agree\u00adment, Bris\u00adtol Myers Squibb will receive exclu\u00adsive rights to Tubu\u00adlis\u2019 proprie\u00adtary conju\u00adga\u00adtion plat\u00adforms for the deve\u00adlo\u00adp\u00adment of a select number of highly diffe\u00adren\u00adtia\u00adted ADCs for [\u2026]<\/p>\n","protected":false},"author":2,"featured_media":48387,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"wp_typography_post_enhancements_disabled":false,"footnotes":""},"categories":[886,1364,1366,1369,1371],"tags":[],"class_list":["post-48385","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-en","category-featured-en","category-news-en","category-investors","category-deals-en"],"yoast_head":"\nm4 Award winner Tubulis enters into billion-dollar agreement with BMS - FYB Financial Yearbook<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fyb.de\/en\/m4-award-winner-tubulis-enters-into-billion-dollar-agreement-with-bms\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"m4 Award winner Tubulis enters into billion-dollar agreement with BMS - FYB Financial Yearbook\" \/>\n<meta property=\"og:description\" content=\"Munich\/ Martins\u00adried, Germany \u2014 Tubu\u00adlis and Bris\u00adtol Myers Squibb have ente\u00adred into a stra\u00adte\u00adgic license agree\u00adment for the deve\u00adlo\u00adp\u00adment of diffe\u00adren\u00adtia\u00adted anti\u00adbody-drug conju\u00adga\u00adtes (ADCs). Under the terms of the license agree\u00adment, Bris\u00adtol Myers Squibb will receive exclu\u00adsive rights to Tubu\u00adlis\u2019 proprie\u00adtary conju\u00adga\u00adtion plat\u00adforms for the deve\u00adlo\u00adp\u00adment of a select number of highly diffe\u00adren\u00adtia\u00adted ADCs for […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fyb.de\/en\/m4-award-winner-tubulis-enters-into-billion-dollar-agreement-with-bms\/\" \/>\n<meta property=\"og:site_name\" content=\"FYB Financial Yearbook\" \/>\n<meta property=\"article:published_time\" content=\"2023-04-22T10:29:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.fyb.de\/wp-content\/uploads\/2023\/04\/08603aa1-9b26-4978-ae69-c0e9fbe3d0c0.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"582\" \/>\n\t<meta property=\"og:image:height\" content=\"295\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Tatjana Anderer\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Tatjana Anderer\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.fyb.de\/en\/m4-award-winner-tubulis-enters-into-billion-dollar-agreement-with-bms\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.fyb.de\/en\/m4-award-winner-tubulis-enters-into-billion-dollar-agreement-with-bms\/\"},\"author\":{\"name\":\"Tatjana Anderer\",\"@id\":\"https:\/\/www.fyb.de\/en\/#\/schema\/person\/4308b3086925bc8567ceba3ebd69b4ce\"},\"headline\":\"m4 Award winner Tubulis enters into billion-dollar agreement with BMS\",\"datePublished\":\"2023-04-22T10:29:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.fyb.de\/en\/m4-award-winner-tubulis-enters-into-billion-dollar-agreement-with-bms\/\"},\"wordCount\":376,\"publisher\":{\"@id\":\"https:\/\/www.fyb.de\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.fyb.de\/en\/m4-award-winner-tubulis-enters-into-billion-dollar-agreement-with-bms\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.fyb.de\/wp-content\/uploads\/2023\/04\/08603aa1-9b26-4978-ae69-c0e9fbe3d0c0.jpeg\",\"articleSection\":[\"General\",\"Featured\",\"News\",\"Investors\",\"DEALS\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.fyb.de\/en\/m4-award-winner-tubulis-enters-into-billion-dollar-agreement-with-bms\/\",\"url\":\"https:\/\/www.fyb.de\/en\/m4-award-winner-tubulis-enters-into-billion-dollar-agreement-with-bms\/\",\"name\":\"m4 Award winner Tubulis enters into billion-dollar agreement with BMS - 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